TAFNAT 25MG

TAFNAT 25MG

Drug profile for Tafnat tablet

tafnat 25mg tablet are primarily used in hepatitis infection condition, is in chronic stage.

tafnat 25mg  tablets are only used by the patients who are having a valid prescription

tafnat  tablets are containing an anti-viral agent known as Tenofovir Alafenamide which may not cure the infection but may suppress the growth of virus.

 PRODUCT DETAILS

Trade name: Tafnat

Active component: Tenofovir Alafenamide

Strength: 25mg

Mfg: natco pharma

Pack: 30 tablets in a container

Category: Anti-hepaciviral activity 
Price : tafnat 25mg price in India

Prescribing information of Tafnat

The tafnat 25mg tablet is most frequently used anti-viral agent like Tenofovir Alafenamide is primarily indicated for the treatment of chronic hepatitis B viral infection occurred in adults’ patient with compensated liver damage.

Mechanism of Tafnat

tafnat 25mg  worked in the body by some component incorporates;

For the most part tafnat  containing tenofovir Alafenamide is a prodrug which is changed over into dynamic frame in-vivo

Tenofovir Alafenamide has cell penetrability property which is lipophilic in nature, infiltrates into hepatocytes by latent dissemination strategy and additionally by hepatic return transporters OATP1B1 and OATP1B3

In-vivo, tenofovir Alafenamide is changed into tenofovir a parent compound by experiencing hydrolysis with the chemical carboxylesterase 1 which is happen in hepatocytes cell

This dynamic frame tenofovir is phosphorylated into tenofovir diphosphate by cell kinase compounds

tafnat 25mg  has pharmacologically dynamic compound known as tenofovir diphosphate which is in charge of viral multiplication denial by means of imbuing into infection DNA with the assistance of turnaround transcriptase chemical which causes viral DNA chain end

Absorption

Maximum plasma concentration time of TAF 0.48 hours

Distribution

tafnat 25mg tablet is largely bound to human plasma protein at 80%

Protein binding data occurs in vivo

The blood plasma ratio of TAF is 1.0 

Metabolism

The metabolism of TAF occurs with the help of;

Carboxyl esterase 1

Cathepsin A

CYP3A

Excretion

Nearly 80% of TAF get metabolized and reaches its half life at 0.51 hour

<1% of metabolite released through urine

31.7% excreted via feces

When to take the Tafnat tablets

tafnat 25mg tabletshould be taken with food

Dosage regimens of Tafnat

Before initiate the treatment with tafnat 25mg tablets, patients must be investigated whether they are suspected with HIV 1 infection or not.

The suggested dosage of tafnat  is 25mg should be administered as a single dose.

In both mild to moderate liver and kidney impaired patients, dosage adjustment should not be allowed; whereas severe conditions, Tafnat not recommended.

Tafnat caused side effects

The most serious adverse effects;

Serious exacerbation of hepatitis B infection

Out breaking or worsening of renal damage

Lactic acidosis

Hepatomegaly with steatosis

Common side effects;

Fatigue

Headache

Cough

Back pain

Nausea

Abdominal pain

Loss of bone mineral density

Glycosuria

Increase in lipase & amylase

Increasing in serum lipids

Drug- drug interaction of Tafnat

tafnat 25mg tablet with P-gp or BCRP inhibiting drugs, causes variation in absorption of TAF; this may leads to adverse effects.

tafnat 25mg  tablets with P gp or BCRP inducing drugs causes depletion of absorption of TAF leads to increasing the concentration of TAF

tafnat 25mg  tablets with renal function reducing drugs may leads to increasing the concentration and causes serious adverse effects

tafnat 25mg tablet combined with anti-convulsants leads to decreasing the effect of concentration of TAF

tafnat 25mg  tablet combined with anti-mycobacterials causes reducing the effect of concentration of TAF

tafnat 25mg tablet tablets concomitant use of herbal product like st, John’s wort, causes decreasing the TAF concentration.

Food drug interaction of Tafnat;

Minor food drug interaction may occur; alcohol containing food items should not be suggested.

Consult with physician about the dietary.

Possible contraindications of Tafnat

No specific contraindication occurs, if some patients may contraindicate to TAF causes anaphylactic reactions.

Safety measures

Aggravation of hepatitis B infection: Check the patient history before starting the treatment

Exposure of advancement of HIV-1 resistance: Due to this condition, tafnat 25mg tablet are not suggested for HIV-1 infections

New commencement of renal damage: To avoid concomitant use of tafnat 25mg  with renal function depleting drugs

Lactic acidosis or hepatomegaly with steatosis: Stop the therapy with tafnat  

Pregnancy and lactation

tafnat 25mg tablet are probably used in pregnancy conditions, only after knowing the risk of the product associated to fetus.

Breast feeding should not be suggested.

Storage and handling

tafnat 25mg  tablet container should be kept at below 30^oC

Protect the container from heat, moisture & heat 

Missed dose

In case of missed dose, get advice from medical practitioner and their instruction; otherwise avoid the missed dose and follow the regular schedule.

Over dosage

If over dosage occurs during the therapy;

Provide the patients with supportive measures

Monitor the signs & symptoms

Hemodialysis is done, to eliminate the TAF content with the range of 54%.

CONTACT US

EMAIL ID : millionhealthpharmaceuticals@gmail.com
PHONE NO : +91-9940472902

WEBSITE URL : https://pillsbag.com/products/tafnat-25mg

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