RITUXIREL 100MG
DESCRIPTION
Rituxirel 100mg is an anticancer medicine which prevents the growth and spread of cancer cells in the body. Rituxirel 100mg injection also indicated for the treatment of Non- Hodgkin’s lymphoma or chronic lymphocytic and with combination with another anticancer drugs like methotrexate is used for rheumatoid arthritis symptoms in adult treatment. Rituxirel 100mg with steroid regimen combination is given for the treatment of some rare disorders which cause blood vessels and other tissues inflammation in the body.INDICATION
Rituxirel 100mg injection and hyaluronidase human injection are given alone or combination with other drugs to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC).Rituxirel 100mg injection is also used with methotrexate (Otrexup, Rasuvo, Xatmep, others) for the treatment rheumatoid arthritis symptoms in adults that have been already treated with some type of regimen known as tumor necrosis factor (TNF) inhibitor.
Rituxirel 100mg injection is a type in a classification of drugs called monoclonal antibodies.
Rituxirel 100mg is used to killing cancer cells to treat NHL, CLL, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by stopping the activity of the part of the immune system that will damage the joints, veins, and other blood vessels and cause damage to organs (heart and lungs).
An essential cells only aimed by monoclonal antibiotics, they may leads to less toxicity to healthy cell and it is usually treatment recommended only for cancers in which antigens (and the respective antibodies) have been already identified.
Rituxirel 100mg works by linking to the CD20 antigen on normal and malignant B-cells. Hence the body's essential immune security is initiated to attack and kill the marked B-cells. Stem cells i.e. young cells in the bone marrow which will grow into the various cell types and do not have the CD20 antigen. After treatment, CD20 antigen allows healthy B-cells to multiply
Ingredients : Rituximab
Strength : 100mg
Manufactured : Reliance Life sciences
Package : 100mg in a 1vial
Price : rituxirel 100mg price in India
Not available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Rituxirel 100mg metabolized by human antimurine antibody production.
EXCRETION
Not available
The half-life of NHL is 22 days and for RA is 18.0 days, GPA and microscopic polyangiitis is 23 day
Successive infusion: 100 mg/hr.-initiated rate, in not showing infusion toxicity, rate raised up to 100 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
Premedication with corticosteroids must be considered, if Rituxirel 100mg combination with CHOP chemotherapy is not given.
Once weeks for 4 or 8 doses administrated for Relapsed treatment
Relapsed Retreatment for once weekly for 4 doses administrated.
Untreated Previously: given on day 1 of each cycle of chemotherapy, up to 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Rituxirel 100mg injection in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent.
Once weekly for 4 doses at intervals of 6 months and max of 16 dose for Non – progression (following CVP chemotherapy completion 6 – 8 cycles)
On day 1 each cycle of chemotherapy up to 8 infusions for Diffuse large B- cell NHL.
Before to Rituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin 7–9 days.
Rituxirel administrating as two doses of 100mg IV infusion 2 weeks separated.
When glucocorticoids administered as methyl prednisolone 100mg IV
Subsequent course based on clinical evaluation should administer every 24 weeks, but not early than every 16 weeks.
While Glucocorticoids combination with methylprednisolone by dose of 1000 mg IV/ day given for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vasculitis . This drug should initiate within 14 days before or with the starting of Rituxirel and may continue during and after the 4-week course with treatment of Rituxirel 100mg injection drug. Safety and not established for subsequent infusion.
Concerning your history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor.
While using Rituxirel 100mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Rituxirel 100mg injection if you are pregnant. It will harm the baby unborn, while using Rituxirel 100mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Rituxirel 100mg injection may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Rituxirel 100mg passes into breast milk, avoid breast-feed while on Rituxirel 100mg treatment.
fever and chills (flu like symptoms)
Less common side effects:
Weakness; nausea; headache; cough; dyspnea; pharyngitis
Combination with fludarabine or cyclophosphamide has no effects in pharmacokinetics in CLL patients.
Combination with methotrexate had no effects in pharmacokinetics.
• Use the drug before expiry date
• Protected from direct sunlight
• Do not freeze or shake.
• Keep away from the children’s
• Discard the unused drug by asking the advice from doctor or pharmacist.
PHONE NO : +91-9940472902
MECHANISM OF ACTION
Rituxirel 100mg injection is a type of class called as monoclonal antibody and which is a new type of "targeted" cancer treatment and an integral part of the body's immune system. Naturally the body build antibodies in along with to an antigen which has entered the body and attach to the antigen for destruction by the immune system.An essential cells only aimed by monoclonal antibiotics, they may leads to less toxicity to healthy cell and it is usually treatment recommended only for cancers in which antigens (and the respective antibodies) have been already identified.
Rituxirel 100mg works by linking to the CD20 antigen on normal and malignant B-cells. Hence the body's essential immune security is initiated to attack and kill the marked B-cells. Stem cells i.e. young cells in the bone marrow which will grow into the various cell types and do not have the CD20 antigen. After treatment, CD20 antigen allows healthy B-cells to multiply
PRODUCT DETAILS
Brand : RituxirelIngredients : Rituximab
Strength : 100mg
Manufactured : Reliance Life sciences
Package : 100mg in a 1vial
Price : rituxirel 100mg price in India
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Rituxirel 100mg |
PHARMACOKINETICS
ABSORPTIONNot available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Rituxirel 100mg metabolized by human antimurine antibody production.
EXCRETION
Not available
The half-life of NHL is 22 days and for RA is 18.0 days, GPA and microscopic polyangiitis is 23 day
DOSAGE MANAGEMENT
Rituxirel 100mg injection is recommended to administer only through intravenous infusion not by IV push or bolus.
BEFORE EACH INFUSION PREMEDICATE
First infusion: initially rate of 50 mg/hr. is given, in not showing infusion toxicity, rate raised up to 50 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.Successive infusion: 100 mg/hr.-initiated rate, in not showing infusion toxicity, rate raised up to 100 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
Premedication with corticosteroids must be considered, if Rituxirel 100mg combination with CHOP chemotherapy is not given.
LOW GRADE OR FOLLICULAR NON-HODGKINS LYMPHOMA
Dose is 375 mg/m2 as an IV infusion.Once weeks for 4 or 8 doses administrated for Relapsed treatment
Relapsed Retreatment for once weekly for 4 doses administrated.
Untreated Previously: given on day 1 of each cycle of chemotherapy, up to 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Rituxirel 100mg injection in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent.
Once weekly for 4 doses at intervals of 6 months and max of 16 dose for Non – progression (following CVP chemotherapy completion 6 – 8 cycles)
On day 1 each cycle of chemotherapy up to 8 infusions for Diffuse large B- cell NHL.
CHRONIC LYMPHOCYTIC LEUKEMIA
Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.COMPONENT OF ZEVALIN FOR TREATMENT OF NHL
Prior to the administration of Indium-111-(In-111-) Zevalin and Yttrium-90- (Y-90-) Zevalin administer Rituxirel 100mg infusion about 250 mg/m2 within 4 hoursBefore to Rituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin 7–9 days.
RHEUMATOID ARTHRITIS
Rituxirel 100mg injection is administer with methotrexate combinationRituxirel administrating as two doses of 100mg IV infusion 2 weeks separated.
When glucocorticoids administered as methyl prednisolone 100mg IV
Subsequent course based on clinical evaluation should administer every 24 weeks, but not early than every 16 weeks.
GRANULOMATOSIS POLYANGITIS AND MICROSCOPIC POLYANGITIS
Weekly once for 4 weeks administer Dose of 375 mg/m2 IV infusionWhile Glucocorticoids combination with methylprednisolone by dose of 1000 mg IV/ day given for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vasculitis . This drug should initiate within 14 days before or with the starting of Rituxirel and may continue during and after the 4-week course with treatment of Rituxirel 100mg injection drug. Safety and not established for subsequent infusion.
ADMINISTRTION
Take an Rituxirel 100mg amount and diluted to final concentration of 1 mg/ml up to 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Invert gently the bag and mix the solution. Dispose unused drug left in vial.PRECAUTIONS
Allergic condition against Rituxirel 100mg injection or any other medication informs your doctor.Concerning your history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor.
While using Rituxirel 100mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Rituxirel 100mg injection if you are pregnant. It will harm the baby unborn, while using Rituxirel 100mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Rituxirel 100mg injection may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Rituxirel 100mg passes into breast milk, avoid breast-feed while on Rituxirel 100mg treatment.
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Non-Hodgkin's lymphoma |
SIDE EFFECTS
Common effects:fever and chills (flu like symptoms)
Less common side effects:
Weakness; nausea; headache; cough; dyspnea; pharyngitis
DRUG INTERACTION
Rituxirel 100mg drug interaction has limited data is available at present.Combination with fludarabine or cyclophosphamide has no effects in pharmacokinetics in CLL patients.
Combination with methotrexate had no effects in pharmacokinetics.
CONTRAINDICATIONS
Hypersensitivity or murine proteins. Active severe infections in rheumatoid arthritis Uncontrolled cardiac disease.PREGNANCY
Category C: animal studies reproduction shown an adverse effect on the fetus. The drug has no enough and well controlled studies in humans, using in pregnant women benefits by warrant use of the drug.LACTATION
Rituxirel 100mg injection excreted into human milk is unknown. Due to the drug belongs to large protein molecule, no information is available. Women should not breast feed during Rituxirel 100mg treatment and 12 months following last dose.STORAGE
• Store at 20°C – 30°C• Use the drug before expiry date
• Protected from direct sunlight
• Do not freeze or shake.
• Keep away from the children’s
• Discard the unused drug by asking the advice from doctor or pharmacist.
MISSED DOSE
If a dose missed to take at the time then have it suddenly before next dose timing, if time reach for next dose, then skip missed dose and continue and continue the regular schedule. Do not have 2 doses at a same time.OVERDOSAGE
If the patients had high dose of Rituxirel 100mg injection then seek immediately to the emergency department or poison control help line. Please consult the doctor for further clarification.CONTACT US
EMAIL ID : millionhealthpharmaceuticals@gmail.comPHONE NO : +91-9940472902
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