MABTAS 100MG
DESCRIPTION
Mabtas 100mg is a anticancer medicine which prevents the growth and spread of cancer cells in the body. Mabtas 100mg injection also indicated for the treatment of Non- Hodgkins lymphoma or chronic lymphocytic and with combination with another anticancer drugs like methotrexate is used for rheumatoid arthritis symptoms in adult treatment.Mabtas 100mg with steroid regimen combination is given for the treatment of some rare disorders which cause blood vessels and other tissues inflammation in the body.
INDICATION
Mabtas 100mg injection and hyaluronidase human injection are given alone or combination with another drugs to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC). Mabtas 100mg injection is also used with methotrexate (Otrexup, Rasuvo, Xatmep, others) for the treatment rheumatoid arthritis symptoms in adults that have been already treated with a some type of regimen known as tumor necrosis factor (TNF) inhibitor. Mabtas 100mg is a type in a classification of drugs called monoclonal antibodies. Mabtas 100mg injection is used to killing cancer cells to treat NHL , CLL, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by stopping the activity of the part of the immune system that will damage the joints, veins, and other blood vessels and cause damage to organs (heart and lungs).PHARMACODYNAMIC
new type of "targeted" cancer treatment and an integral part of the body's immune system. Naturally the body build antibodies in along with to an antigen which has entered the body and attach to the antigen for destruction by the immune system. An essential cells only aimed by monoclonal antibiotics, they may leads to less toxicity to healthy cell and it is usually treatment recommended only for cancers in which antigens (and the respective antibodies) have been already identified. Mabtas works by linking to the CD20 antigen on normal and malignant B-cells. Hence the body's essential immune security are initiated to attack and kill the marked B-cells. Stem cells i.eyoung cells in the bone marrow which will grow into the various cell types and do not have the CD20 antigen. After treatment,CD20 antigen allows healthy B-cells to multiplyPRODUCT DETAILS
Brand : MabtasIngredients : Rituximab
Strength : 100mg
Manufactured : Intas pharmaceuticals
Package : injection
Price : mabtas 100mg price in India
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Mabtas 100mg |
PHARMACOKINETICS
ABSORPTIONNot available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Mabtas 100mg injection metabolized by human antimurine antibody production.
EXCRETION
not available The half life of NHL is 22 days and for RA is 18.0 days, GPA and microscopic polyangitis is 23 days
DOSAGE MANAGEMENT
Mabtas 100mg is recommended to administer only through intravenous infusion not by IV push or bolus.
BEFORE EACH INFUSION PREMEDICATE
First infusion: initially rate of 50 mg/hr is given , in not showing infusion toxicity, rate raised upto 50 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Successive infusion: 100 mg/hr initiated rate , in not showing infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Premedication with corticosteroids must be considered, if
First infusion: initially rate of 50 mg/hr is given , in not showing infusion toxicity, rate raised upto 50 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Successive infusion: 100 mg/hr initiated rate , in not showing infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Premedication with corticosteroids must be considered, if
Mabtas 100mg injection combination with CHOP chemotherapy is not given.
LOW GRADE OR FOLLICULAR NON-HODGKINS LYMPHOMA
Dose is 375 mg/m2 as an IV infusion. Once weeks for 4 or 8 doses administrated for Relapsed treatment Relapsed Retreatment for once weekly for 4 doses administrated. Untreated Previously: given on day 1 of each cycle of chemotherapy, upto 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Mabtas 100mg in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent. Once weekly for 4 dose at intervals of 6 months and max of 16 dose for Non – progression (following CVP chemotherapy completion 6 – 8 cycles) On day 1 each cycle of chemotherapy upto 8 infusions for Diffuse large B- cell NHL.
Dose is 375 mg/m2 as an IV infusion. Once weeks for 4 or 8 doses administrated for Relapsed treatment Relapsed Retreatment for once weekly for 4 doses administrated. Untreated Previously: given on day 1 of each cycle of chemotherapy, upto 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Mabtas 100mg in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent. Once weekly for 4 dose at intervals of 6 months and max of 16 dose for Non – progression (following CVP chemotherapy completion 6 – 8 cycles) On day 1 each cycle of chemotherapy upto 8 infusions for Diffuse large B- cell NHL.
COMPONENT OF ZEVALIN FOR TREATMENT OF NHL
Prior to the administration of Indium-111-(In-111-) Zevalin and Yttrium-90- (Y-90-)Zevalin administer Mabtas 100mg injection infusion about 250 mg/m2 within 4 hours Before toRituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin 7–9 days.
Prior to the administration of Indium-111-(In-111-) Zevalin and Yttrium-90- (Y-90-)Zevalin administer Mabtas 100mg injection infusion about 250 mg/m2 within 4 hours Before toRituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin 7–9 days.
CHRONIC LYMPHOCYTIC LEUKEMIA
Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.
Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.
RHEUMATOID ARTHRITIS
Mabtas 100mg is administer with methotrexate combination Mabtas 100mg injection administrating as two dose of 100mg IV infusion 2 weeks separated. When glucocorticoids administered as methyl prednisolone 100mg IV Subsequent course based on clinical evaluation should administer every 24 weeks, but not early than every 16 weeks.
Mabtas 100mg is administer with methotrexate combination Mabtas 100mg injection administrating as two dose of 100mg IV infusion 2 weeks separated. When glucocorticoids administered as methyl prednisolone 100mg IV Subsequent course based on clinical evaluation should administer every 24 weeks, but not early than every 16 weeks.
GRANULOMATOSIS POLYANGITIS AND MICROSCOPIC POLYANGITIS
Weekly once for 4 weeks administer Dose of 375 mg/m2 IV infusion While Glucocorticoids combination with methylprednisolone by dose of 1000 mg IV/ day given for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vasculitis . This drug should intiate within 14 days before or with the starting of Mabtas 100mg injection and may continue during and after the 4 week course with treatment of Mabtas 100mg drug. Safety and not established for subsequent infusion.
Weekly once for 4 weeks administer Dose of 375 mg/m2 IV infusion While Glucocorticoids combination with methylprednisolone by dose of 1000 mg IV/ day given for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vasculitis . This drug should intiate within 14 days before or with the starting of Mabtas 100mg injection and may continue during and after the 4 week course with treatment of Mabtas 100mg drug. Safety and not established for subsequent infusion.
ADMINISTRATION
Take an Mabtas 100 mg injection amount and diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Invert gently the bag and mix the solution. Dispose unused drug left in vial.
Take an Mabtas 100 mg injection amount and diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Invert gently the bag and mix the solution. Dispose unused drug left in vial.
OVERDOSAGE: If the patients had high dose of Mabtas 100mg then seek immediately to the emergency department or poison control help line. Please consult the doctor for further clarification.
Allgeric condition against Mabtas 100mg injection or any other medication informs your doctor. Concerning your past history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor. While using Mabtas 100mg do not take any vaccination or immunization without taking advice from doctors. Avoid use of Mabtas 100mg injection if you are pregnant. It will harm the baby unborn, while using Mabtas 100mg injection use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Mabtas 100mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant. It is unknown whether Mabtas 100mg passes into breast milk , avoid breast-feed while on Mabtas 100mg injection treatment.
PRECAUTIONS
Allgeric condition against Mabtas 100mg or any other medication informs your doctor. Concerning your past history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor. While using Mabtas 100mg injection do not take any vaccination or immunization without taking advice from doctors. Avoid use of Mabtas 100mg if you are pregnant. It will harm the baby unborn, while using Mabtas 100mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends.
Allgeric condition against Mabtas 100mg injection or any other medication informs your doctor. Concerning your past history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor. While using Mabtas 100mg do not take any vaccination or immunization without taking advice from doctors. Avoid use of Mabtas 100mg injection if you are pregnant. It will harm the baby unborn, while using Mabtas 100mg injection use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Mabtas 100mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant. It is unknown whether Mabtas 100mg passes into breast milk , avoid breast-feed while on Mabtas 100mg injection treatment.
PRECAUTIONS
Allgeric condition against Mabtas 100mg or any other medication informs your doctor. Concerning your past history of drug used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor. While using Mabtas 100mg injection do not take any vaccination or immunization without taking advice from doctors. Avoid use of Mabtas 100mg if you are pregnant. It will harm the baby unborn, while using Mabtas 100mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends.
Mabtas 100mg injection may affect the ability to have children in women. Inform your doctor if you planning to pregnant. It is unknown whether Mabtas 100mg passes into breast milk , avoid breast-feed while on Mabtas 100mg injection treatment.
SIDE EFFECTS
COMMON EFFECTS
fever and chills (flu lik symptoms)LESS COMMON SIDE EFFECTS
Weakness; nausea; headache; cough; dyspnae; pharyngitis
DRUG INTERACTION
Mabtas 100mg drug interaction has limited data is available at present. Combination with fludarabine or cyclophosphamide has no effects in pharmacokinetics in CLL patients. Combination with methotrexate had no effects in pharmacokinetics.CONTRAINDICATIONS
Hypersensitivity or murine proteins. Active severe infectons in rheumatoid arthritis Uncontrolled cardiac disease.PREGNANCY
CategoryC : animal studies reproduction shown an adverse effect on the fetus. The drug has no sufficient and well controlled studies in humans, using in pregnant women benefits by warrant use of the drug.LACTATION
Mabtas 100mg injection excreted into human milk is unknown. Due to the drug belongs to large protein molecule, no information is available. Women should not breast feed during Mabtas 100mg treatment and 12 months following last dose.STORAGE
Store at 2°C – 3°CUse the drug before expiry date
Protected from direct sunlight
Do not freeze or shake.
Keep away from the childerns
Discard the unused drug by asking the advice from doctor or pharmacist.
MISSED DOSE
Store at 2°C – 3°CUse the drug before expiry date
Protected from direct sunlight
Do not freeze or shake.
Keep away from the childerns
Discard the unused drug by asking the advice from doctor or pharmacist.
CONTACT US
EMAIL ID : millionhealthpharmaceuticals@gmail.com
PHONE NO : +91-9940472902
WEBSITE URL : https://millionpharma.com/mabtas-100mg.php
KEYWORDS : mabtas 100mg,mabtas 100mg injection,mabtas 100mg price in India
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