Xovoltib 40mg tablet| Afatinib Uses & Side effects | MHP

XOVOLTIB 40MG

DESCRIPTION:

This is a Phase 2 trial examine the performance of a targeted cancer drug known as Xovoltib 40mg.
Xovoltib 40mg tablet prohibits the EGFR protein, which is accepting to be included in driving the growth of chordoma tumors.This study is plan specifically for chordoma patients 18 years or older with recurrent or metastatic tumors. Xovoltib 40mg which is used as prescription drugs under the guidance of oncologist physician.

INDICATION:

Xovoltib 40mg tablet is used for the first-line treatment for patients with metastatic non-small cell lung cancer(NSCLC)

MECHANISM OF ACTION:

Afatinib (Xovoltib 40mg tablet ) mechanism by preventing the activity of a group of proteins knowns as epidermal growth factor receptors (EGFR). Epidermal growth factor receptor is a protein which is included in the growth and spread of cancer cells; Afatinib(Xovoltib 40mg) works by inhibiting the action of this protein.
Afatinib(Xovoltib 40mg tablet ) should not be taken by people who having EGFR-negative tumors.

PRODUCT DETAILS:

Brand : Xovoltib
Ingredients : Afatinib
Strength : 40mg
Manufactured : GSK pharmaceuticals
Package : 7 tablets in a strip
Price : xovoltib 40mg price in India

Xovoltib 40mg

PHARMACOKINETICS:

• Time to peak plasma time is 2-5 hr and bioavailability are 92 %
• Human plasma protein bound is 95%
• The major circulating metabolites are covalent adducts to proteins.
• The drug excretion through feces is 85% and urine 4% • Half-life is 37 hr.

DOSAGE MANAGEMENT:

For adult: 40mg taken once per day is the prescribed dose for adult patients with metastatic non-small cell lung cancer Age of 0-17 years prescribed dose is not being studied in children.

Avoid using of Xovoltib 40mg tablet drug under 18 years of age

The prescribed dose for renal impairment is given 30mg taken once per day

Administration :

Administer the drug Xovoltib 40mg on an empty stomach.
Take the drug Xovoltib 40mg tablet 1 hour before or 2 hours after a meal
Avoid cutting or crushing the tablet
Overdosage : Overdose is reported in patients whom ingested 360mg of Xovoltib which causes in nausea, vomiting, asthenia, abdominal pain and hence provided supportive measurement for recovery.

PRECAUTIONS:

Serious dehydration can occur with the use of Xovoltib 40mg . This may be leads to serious or persistent diarrhea, vomiting, or reduced fluid intake. Dehydration can result in kidney failure, if it is severe enough. While on treatment with this medication, you may be encouraged to drink extra water.
During treatment with Xovoltib 40mg tablet will result in hepatotoxicity; monitor with periodic liver testing; withhold or stoptreatment for serious or worsening liver tests.The drug may result in Interstitial lung disease (ILD).when administrated to pregnant women, Xovoltib 40mg will have foetus harm (embryo-fetal toxicity)Discontinue the drug,if patients confirm with suspected keratitis or ulcerative keratitis With Xovoltib 40mg tablet have increased sunburn/phototoxicity; may aggravate rash or acne; patients use with caution to limit sun exposure and where sunscreen and protective clothing.
sometimes, Xovoltib 40mg has been bind to corneal perforation, a serious injury to the part of the eye which focuses light into the eye. If you have any persistent eye pain or changes in vision, inform your doctor immediately.

SIDE EFFECTS:

Common side effects caused Xovoltib 40mg tablet  :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other signs of infection around your fingernails or toenails

Serious side effects Xovoltib 40mg  :
• Eye problems – blurred vision, watery eyes, increased sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins

DRUG INTERACTION:

Co administration of Xovoltib 40mg with P-gp inhibitors (cyclosporine A, ketoconazole verapamil) will have high exposure to Afatinib (Xovoltib 40mg tablet )
When interaction of Xovoltib 40mg tablet with P-gp inducers (carbamazepine, phenytoin, phenobarbital) will lowers the exposure to Afatinib (Xovoltib 40mg)

MISSED DOSE:

If patient missed to take the dose of Xovoltib 40mg, then the missed dose must be skipped and follow the regular dosing schedule. Do not administerdouble the dose
Consult with doctor and follow the suggestions.

PREGNANCY:

Pregnancy category: c
During treatment with Xovoltib 40mg tablet Pregnancy should avoid because the drug Xovoltib 40mg is administrated to a pregnant woman will harm the foetus.

LACTATION:

Xovoltib 40mg Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed. Hence decision can take whether to stop breastfeeding or discontinuation of medicine.

STORAGE:

• Xovoltib 40mg tablet Store at 25°C
• Keep Xovoltib 40mg away from children
• Protect away free from moisture and light.

CONTACT US:

ADDRESS : Portion 'A' First Floor,

                     Old No. 131, New No. 50,
                     Pedariyar Kovil Street,
                     Seven Wells, Chennai - 600001.
                     Tamilnadu,India

PHONE NO : +91-9940472902

EMAIL ID : millionhealthpharmaceuticals@gmail.com

WEBSITE URL: https://millionpharma.com/xovoltib-40mg.php

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